Ruthenium (IV) oxide

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

transformation / dissolution of metals and inorganic metal compounds

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media

Qualifier:

according to guideline

Guideline:

other: UN Transformation/Dissolution Protocol (T/DP) for Metals and Sparingly Soluble Metal Compounds.

GLP compliance:

no

Type of method:

other: Transformation/dissolution

Type of test:

screening transformation/dissolution test - sparingly soluble metal compounds

Mean dissolved conc.:

0.9 µg/L

Element analysed:

ruthenium

Loading of aqueous phase:

100 mg/L

Incubation duration:

24 h

Test conditions:

pH 6

Type of test:

screening transformation/dissolution test - sparingly soluble metal compounds

Mean dissolved conc.:

0.17 µg/L

Element analysed:

ruthenium

Loading of aqueous phase:

100 mg/L

Incubation duration:

24 h

Test conditions:

pH 8.5

Type of test:

full transformation/dissolution test - metals and sparingly soluble metal compounds

Mean dissolved conc.:

0 µg/L

Element analysed:

ruthenium

Loading of aqueous phase:

1 mg/L

Incubation duration:

28 d

Test conditions:

pH 6

Type of test:

full transformation/dissolution test - metals and sparingly soluble metal compounds

Mean dissolved conc.:

0 µg/L

Element analysed:

ruthenium

Loading of aqueous phase:

10 mg/L

Incubation duration:

7 d

Test conditions:

pH 6

Type of test:

full transformation/dissolution test - metals and sparingly soluble metal compounds

Mean dissolved conc.:

0.08 µg/L

Element analysed:

ruthenium

Loading of aqueous phase:

100 mg/L

Incubation duration:

7 d

Test conditions:

pH 6

Details on results:

The 24-hour scoping study for ruthenium (IV) oxide indicate a lack of reactivity, 0.9 and 0.17 µg/L at pH 6 and pH 8.5, respectively. In the definitive tests at pH 6, there were no net concentration changes for ruthenium (IV) oxide in the 1 and 10 mg/L loadings. In the 100 mg/L loadings, the net concentration of Ru increased to ~0.10 µg/L (σ % = 13) at 6 hours, before declining slightly to 0.08 µg/L at seven days.

Conclusions:

In the definitive tests at pH 6, there were no net concentration changes for ruthenium (IV) oxide in the 1 and 10 mg/L loadings, after 28 and 7 days respectively. In the 100 mg/L loading, the net concentration of Ru increased to ~0.10 µg/L (σ % = 13 ) at 6 hours, before declining slightly to 0.08 µg/L at 7 days.

Executive summary:

Skeaff and Beaudoin (2011) follows a standard test guideline for transformation / dissolution studies and is considered adequate for assessment as a key study for this endpoint.A 24-hour screening study was conducted at pH 6 and pH 8.5, followed by a definitive 28-day study at pH 6 with loading rates of 1, 10 and 100 mg L-1.

In the definitive tests at pH 6, there were no net concentration changes for ruthenium (IV) oxide in the 1 and 10 mg/L loadings, after 28 and 7 days respectively. In the 100 mg/L loading, the net concentration of Ru increased to ~0.10 µg/L (σ % = 13) at 6 hours, before declining slightly to 0.08 µg/L at 7 days.

Description of key information

In the definitive tests at pH 6, there were no net concentration changes for ruthenium (IV) oxide in the 1 and 10 mg/L loadings, after 28 and 7 days respectively. In the 100 mg/L loading, the net concentration of Ru increased to ~0.10 µg/L (σ % = 13 ) at 6 hours, before declining slightly to 0.08 µg/L at 7 days.

Key value for chemical safety assessment

Water solubility:

0.1 µg/L

at the temperature of:

22.3 °C

Additional information

Skeaff and Beaudoin (2011) follows a standard test guideline for transformation / dissolution studies and is considered adequate for assessment as a key study for this endpoint. A 24-hour screening study was conducted at pH 6 and pH 8.5, followed by a definitive 28-day study at pH 6 with loading rates of 1, 10 and 100 mg L-1.

In the definitive tests at pH 6, there were no net concentration changes for ruthenium (IV) oxide in the 1 and 10 mg/L loadings, after 28 and 7 days respectively. In the 100 mg/L loading, the net concentration of Ru increased to ~0.10 µg/L (σ % = 13) at 6 hours, before declining slightly to 0.08 µg/L at 7 days.