Registration Dossier
Registration Dossier
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EC number: 232-369-0 | CAS number: 8008-63-7 Extractives and their physically modified derivatives such as proteins, lipids, carbohydrates, nucleic acids, inorganic ions, etc. obtained from mammalian bile.
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2018-05-23 to 2019-02-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: vapour pressure balance
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Temp.:
- 50 °C
- Vapour pressure:
- 0 Pa
- Conclusions:
- The vapour pressure was calculated to be 6.34E-6 Pa at 20 °C, 9.68E-6 Pa at 25 °C and 6.60E-5 Pa at 50 °C, respectively.
- Executive summary:
A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance. The vapour pressure of the test item was determined at temperatures between 112 and 153 °C. The vapour pressure was calculated for a mean molecular weight of 500 g/mol. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure was calculated to be 6.34E-6 Pa at 20 °C, 9.68E-6 Pa at 25 °C and 6.60E-5 Pa at 50 °C, respectively.
Reference
The vapour pressure was measured in the temperature range of 112 to 153 °C. Due to the fact that the molecular mass of the test item is between 471 and 521 g/mol, the vapour pressure was calculated for a mean molecular mass of 500 g/mol.
Table 1. Results of the effusion method
| No. | Temperature / °C | Vapour pressure for M = 500 g/mol /Pa |
| 1 | 112 | 2.72E-3 |
| 2 | 122 | 3.86E-3 |
| 3 | 133 | 7.59E-3 |
| 4 | 143 | 1.15E-2 |
| 5 | 153 | 1.59E-2 |
From the measured data points of the vapour pressure curve the constants A and B of the Antoine equation were derived by regression of the data points to M = 500 g/mol:
A = 5.76
B = -3212.31
C = 273.15
The vapour pressure of the test item calculated by extrapolation for the temperatures 20, 25 and 50 °C is the following:
Table 2. Calculated vapour pressure values for 20, 25, 50 °C
| Temperature / °C | Vapour pressure for M = 500 g/mol /Pa |
| 20 | 6.34E-6 |
| 25 | 9.68E-6 |
| 50 | 6.60E-5 |
Description of key information
The vapour pressure was calculated to be 6.34E-6 Pa at 20 °C, 9.68E-6 Pa at 25 °C and 6.60E-5 Pa at 50 °C, respectively.
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 20 °C
Additional information
A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance. The vapour pressure of the test item was determined at temperatures between 112 and 153 °C. The vapour pressure was calculated for a mean molecular weight of 500 g/mol. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure was calculated to be 6.34E-6 Pa at 20 °C, 9.68E-6 Pa at 25 °C and 6.60E-5 Pa at 50 °C, respectively.
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