Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-019-7 | CAS number: 7783-66-6
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity of iodine pentafluoride to microorganisms is derived from experimental data with its degradation products iodide, iodate and fluoride. As no data with iodate and iodide are available for this endpoint, an experimental study with iodine is assessed. In this study a EC10 value of 110 mg/L and a EC50 value of 280 mg/L were determined. After correction for molecular weight, the EC10 and EC50 values for iodate are 76 mg/L and 193 mg/L, respectively. For iodide correction for molecular weight gives EC10 and EC50 values of 55 mg/L and 140 mg/L, respectively.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 140 mg/L
- EC10 or NOEC for microorganisms:
- 55 mg/L
Additional information
No aquatic toxicity studies with iodine pentafluoride are available or can be performed as in contact with water iodine pentafluoride reacts instantly and violently under formation of hydrogen fluoride and iodate. Hydrogen fluoride will further react to fluoride and iodate in water forms an equilibrium with iodide. Therefore available data from studies with fluoride, iodate and iodide are given as indication of the aquatic toxicity of iodine pentafluoride. As no data on iodate and iodide is available, read across is made to the aquatic toxicity data of iodine (I2).
In the EU Risk Assessment Report for hydrogen fluoride several studies with micro-organisms are reported (EU-RAR, 2001). The long-term NOEC-values for microorganisms range from 7.1 to 510 mg/L. In the EU-RAR it is concluded that only the results of an activated sludge test (3h-EC10 value of 510 mg fluoride/L) and a test on Pseudomonas putida (NOEC of 231 mg fluoride/L) can theoretically be used for deriving a PNEC for microorganisms. As the EC10 -value of 510 mg fluoride/L from the activated sludge test brings about the lowest PNEC, this study is concluded to be critical. As no new data have become available since the EU-RAR, this conclusion is adopted for this substance evaluation.
A GLP-compliant OECD guideline 209 study is available for iodine (Notox, 2010). In this 3 -hour respiration inhibition test, activated sludge (from a municipal sewage treatment plant receiving predominantly domestic sewage) was exposed to iodine concentrations of up to 1000 mg/L. Iodine showed significant inhibition of respiration rate of the sludge at and above a loading rate of 100 mg/L. The 3h-EC10 for iodine is 110 mg/L and the 3 h-EC50 is 280 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
