Registration Dossier
Registration Dossier
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EC number: 231-915-5 | CAS number: 7778-80-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In an in vitro Ames test performed according to OECD test guideline 471 potassium sulphate showed no mutagenicity with or without metabolic activation in 4 strains of Salmonella typhimurium (TA98, TA100, TA1535 and TA1537) and in E. coli bacteria (WP2 uvr A).
The substance was tested up to the maximum concentration. In a second in vitro study where chromosome abberrations were tested in CHO cells according to OECD test guideline 473 also no effects were found. A third in vitro study with potassium sulphate is not present, however a negative in vitro TK assay in L5178Y mouse lymphoma cells with magnesium sulphate performed according to OECD 476 was present, showing no genotoxicity.In addition, ammonium sulphate another substance in the sulfate category showed also negative results in genotoxicity studies.
Short description of key information:
Potassium sulfate was found negative in two in vitro studies, an Ames test as well as in a chromosome aberration test in the presence and absence of metabolic activation. In a mouse lymphoma assay, magnesium sulphate was found to be negative. Other genotoxicity studies with substances in the sulfate category showed also negative results.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The available data indicate that no classification is required with regard to mutagenicity for potassium sulphate according to Directive 67/548/EC and the CLP directive.
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