Registration Dossier
Registration Dossier
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EC number: 231-749-3 | CAS number: 7719-12-2
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity
- Remarks:
- other: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: irrelevant route of exposure (i.p.); only few experimental details
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Mechanistic investigation of cholinesterase activity
- GLP compliance:
- no
- Remarks:
- : published study
- Limit test:
- no
Test material
- Reference substance name:
- Phosphorus trichloride
- EC Number:
- 231-749-3
- EC Name:
- Phosphorus trichloride
- Cas Number:
- 7719-12-2
- Molecular formula:
- Cl3P
- IUPAC Name:
- phosphorus trichloride
- Details on test material:
- Phosphorus oxychloride
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss Webster
- Sex:
- male
Administration / exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 10, 30, 100 mg/kg bw
Basis:
other: ip dose
- Control animals:
- yes, concurrent vehicle
Results and discussion
Any other information on results incl. tables
Serum (butyryl)cholinesterase, but not brain acetylcholinesterase was inhibited in vivo 1 h after exposure (ED50 (14 mg/kg bw). Mortality was seen at dose levels of 100 mg/kg bw and above.
Applicant's summary and conclusion
- Conclusions:
- No effects were seen on acetylcholinesterase activity in this study. Butyrylcholinesterase activity was inhibited at high dose levels.
- Executive summary:
Intraperitoneal dosing of mice was found to result in the inhibition of butyrylcholinesterase activity at high dose levels, but did not affect cholinesterase activities. The effects are not of clear physiological relevance.
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