Registration Dossier
Registration Dossier
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EC number: 231-179-5 | CAS number: 7440-70-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Exposure to metallic form of calcium only raises a concern when regarding first contact exposure, the exposure via the two only relevant routes (inhalation and dermal) are assessed in sections 9 and 10 of the CSR. Exposure assessment does not raise a concern for reproductive toxicity when taken together with the properties of calcium ion within human body (section 7.1 of IUCLID). Calcium (ionic) levels are regulated tightly by homeostasis in different compartments of the human body therefore systemic effects are not foreseen. Calcium serves numerous biological, cellular and transmitter properties in the human body as an essential mineral. Ubiquitous presence in the environment as various calcium compounds and presence in human diet usually as ionized soluble forms withholds the necessity for further toxicity testing and risk analysis. Absorption and excretion, as well as homeostasis (intra- and extracellular) of calcium and its metabolites are well known and do not raise a concern for toxicity to reproduction.
Short description of key information:
Exposure for metallic calcium from industrial processes is considered in section 9 of CSR, exposure and RMMs thereafter do not indicate risk beyond first contact effects. Calcium (ionic form) is an essential mineral nutrient, which is tightly regulated by homeostasis. Therefore effects on fertility and teratogenicity are not expected.
Effects on developmental toxicity
Description of key information
Exposure for metallic calcium from industrial processes is considered in section 9 of CSR, exposure and RMMs thereafter do not indicate risk beyond first contact effects. Calcium (ionic form) is an essential mineral nutrient, which is tightly regulated by homeostasis. Therefore effects on fertility and teratogenicity are not expected.
Additional information
Exposure to metallic form of calcium only raises a concern when regarding first contact exposure, the exposure via the two only relevant routes (inhalation and dermal) are assessed in sections 9 and 10 of the CSR. Exposure assessment does not raise a concern for developmental toxicity when taken together with the properties of calcium ion within human body (section 7.1 of IUCLID). Calcium (ionic form) is an essential mineral nutrient, which is tightly regulated by homeostasis. Therefore effects on fertility and teratogenicity are not expected.
Justification for classification or non-classification
Calcium (ionic form) cannot be considered as a risk for reproduction since its levels are regulated within different compartments of the body by homeostasis. Classification of elemental calcium is not therefore warranted.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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