Registration Dossier
Registration Dossier
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EC number: 230-029-6 | CAS number: 6920-22-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
1,2-hexandiol can be absorbed well mainly via oral and dermal exposure (80% absorption assumed). The absorption via inhalation is considered irrelevant due to negligible exposure (i.e. low vapour pressure). No accumulation in the body is expected due to efficient metabolic pathways and formation of soluble degradation products with established elimination routes.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Based on available information, it is expected that 1,2-hexandiol can be absorbed well mainly via oral and dermal exposure (80% absorption assumed). The absorption via inhalation is considered irrelevant due to negligible exposure (i.e. low vapour pressure). Following absorption1,2-hexandiol is expected to be detoxified mainly through oxidation and conjugation. 1,2-Hexandiol and metabolites are proposed to distribute rapidly, mainly in blood, liver and kidney, while a large fraction may be excreted quickly via urine, in the form of glucuronide conjugation and parent compound. No accumulation in the body is expected due to efficient metabolic pathways and formation of soluble degradation products (glucose derivatives) with established elimination routes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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