Registration Dossier
Registration Dossier
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EC number: 229-563-2 | CAS number: 6610-29-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The determination of the growth inhibition of the freshwater algae Pseudokirchneriella subcapitata exposed to the test item 4-methyl-3-thiosemicarbazide for a duration of 72 hours was assessed according to the OECD Guideline 201. ErC50-72h was determined as 30 mg/L
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 30 mg/L
- EC10 or NOEC for freshwater algae:
- 18 mg/L
Additional information
The determination of the growth inhibition of the freshwater algae Pseudokirchneriella subcapitata (previously known as Raphidocelis subcapitata and Selenastrum capricornutum) exposed to the test item 4-methyl-3-thiosemicarbazide for a duration of 72 hours was assessed according to the OECD Guideline 201.
Algae were exposed to 1 to 100 mg
4-methyl-3-thiosemicarbazide
/L dissolved in dilution water. The concentrations of test item causing a 50% reduction in biomass (EbC50) and in growth rate (ErC50) were estimated over a time period of 72 hours. The results were as follows:
Endpoint |
EC50-72h, mg/L (95%CI) |
EC10-72h, mg/L |
Cell growth – Biomass (b) |
26 (ND) |
15 (ND) |
Growth rate – Cell multiplication (r) |
30 (13 – 75) |
18 (2.9-32) |
CI: confidence interval; ND: not determined
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