Registration Dossier
Registration Dossier
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EC number: 228-250-8 | CAS number: 6197-30-4
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.66 µg/L
Additional information
In a 21d Daphnia reproduction study according to OECD 211 and GLP using 14C test material, a NOEC of 2.66 µg/L (mean measured) was derived (BASF SE, DSM Nutritional Products AG, Merck KGaA, Symrise AG, 2018). In this study 5 concentrations have been tested, a clear concentration response on daphnid reproduction was observed.
In contrast, in a scientific publication a NOEC of > 50 µg/L was derived from a 21 d Daphnia reproduction test (non-GLP, no analytics), however some information on the test design and detailed study results are missing. Therefore, the results from the recent GLP study of higher quality should be taken for the hazard assessment of the substance.
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