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EC number: 226-164-5 | CAS number: 5307-14-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
48 hrs aquatic toxicity study (EPI suite, 2016) was conducted to assess toxic effects of the test compound 2-nitro-p-phenylenediamine (CAS no 5307-14-2) and the results were predicted. The study was based on the effects of the test compound on Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 2-nitro-p-phenylenediamine was estimated to be 1249.412 mg/L on the basis of mobility.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1 249.412 mg/L
Additional information
Various studies for the target chemical2-nitro-p-phenylenediamine along with its predicted data and read across substance were reviewed to summarize the following information:
48 hrs aquatic toxicity study (EPI suite, 2016) was conducted to assess toxic effects of the test compound 2-nitro-p-phenylenediamine (CAS no 5307-14-2) and the results were predicted. The study was based on the effects of the test compound on Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 2-nitro-p-phenylenediamine was estimated to be 1249.412 mg/L on the basis of mobility.
48 hrs aquatic toxicity study (SSS QSAR prediction model, 2016) was conducted to assess toxic effects of the test compound 2-nitro-p-phenylenediamine (CAS no 5307-14-2) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 2-nitro-p-phenylenediamine was estimated to be 119.0330 mg/L on the basis of intoxication.
Short term toxicity to aquatic invertebrates test (Enaut Urrestarazu Ramos, et. al; 1998) was studied in L. stagnalis for 96 hrs at 21-24 °C in semi static conditions. 5 snails were exposed, in duplicate, to 1 L test solution in 1.5 L jars. Fresh solution was prepared daily. Chemical analysis in snail experiment was done using solid phase microextraction (SPME) and GC. Determination of lethal body burdens was also done. Based on the experiment, the LC50 value for 3-Nitroaniline was estimated to be 143 mg/l.
On the basis of the above resultsof various predicted data of toxicity to aquatic algae and cyanobacteria for target chemical and its read across substance, it can be concluded thatthe substance can be classified as non- hazardous as per the criteria of CLP regulation.
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