Registration Dossier
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EC number: 225-716-2 | CAS number: 5026-74-4
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Determination of the Hydrolysis values of p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline (496981)
(GLP compliant study based on the OECD Guideline 111, 2004 and EEC 440/2008 Guideline C.7).
Author: Dr. Ir. E. Baltussen
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 2.3 d
- at the temperature of:
- 25 °C
Additional information
Hydrolysis of p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline was studied at 20, 40 and 50 ºC in sterile aqueous buffered solutions at pH 4, pH 7 and pH 9. The hydrolysis at 25oC was estimated based on the Arrheniusequation.
The experiment was conducted in accordance with the EEC directive 440/2008, Guideline C.7 “Degradation - Abiotic Degradation : Hydrolysis as a Function of pH”, and the OECD Guideline 111 "Hydrolysis as a Function of pH”, adopted in April 2004 and in compliance with the GLP standards.
Samples were analysed by HPLC.
| pH 4 | pH 7 | pH 9 | |||
| Temperature [°C] | t½ | Temperature [°C] | t½ | Temperature [°C] | t½ |
| 20 | 3.9 d | 20 | 4.1 d | 20 | 4.6 d |
| 25 | 2.2 d | 25 | 2.3 d | 25 | 2.6 d |
| 40 | 10 h | 40 | 10 h | 40 | 12 h |
| 50 | 3.9 h | 50 | 4.3 h | 50 | 5.7 h |
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