Registration Dossier
Registration Dossier
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EC number: 225-714-1 | CAS number: 5026-62-0
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (21 d) = 0.2 mg/L for Daphnia magna (OECD 211), read across
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.2 mg/L
Additional information
No studies investigating the long-term toxicity of sodium methylparaben (CAS No. 5026-62-0) to aquatic invertebrates are available. Therefore, toxicity data of the corresponding acid methylparaben (CAS No. 99-76-3) are used as read across.
This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach as is explained within the analogue justification in section 13. Except for different cations (hydrogen vs. sodium) the anions of both the source and target substance have identical chemical structures. Since dissociation of the sodium salt under environmental conditions (pH 4 - 9) yields the same ionic species as the acidic form of the substance, this read across can be considered as justified.
For the long-term toxicity of the analogue read across substance methylparaben to aquatic invertebrates one study is available (Mitsubishi Chemical Institute, 2000). The study was carried out according to OECD guideline 211 under GLP conditions. Daphnia magna was exposed under semi-static conditions to a concentration range of 0, 0.10, 0.32, 1.0, 3.2 and 10 mg/L. Mean measured concentrations (time-weighted) were < 80% of nominal for the two lowest concentrations and≥80% of nominal for the higher test concentrations. Based on time-weighted mean measured concentrations a NOEC (21 d) of 0.2 mg/L for reproduction is reported. This value was used for assessment.
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