Denatonium benzoate

Density

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

density, other

Remarks:

Density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

24/08/2015- 25/08/2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Principles of method if other than guideline:

The density was determined for the test substance Denatonium benzoate (CAS No. 3734-33-6) by pour density method following the OECD Guideline 109 for density of solids and liquids and standard method recommended in the International Pharmacopoeia, fourth Edition, 2014.

GLP compliance:

no

Type of method:

other: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014

Specific details on test material used for the study:

- Name of test material (as cited in study report): Denatonium benzoate
- IUPAC NAme : benzyl({[(2,6-dimethylphenyl)carbamoyl]methyl})diethylazanium benzoate hydrate
- Molecular formula: C21H29N2O.C7H5O2
- Molecular weight: 446.58 g/mol
- Smiles : CC[N+](CC)(Cc1ccccc1)CC(=O)Nc2c(cccc2C)C.c1ccc(cc1)C(=O)[O-]
- InChI : 1S/C21H28N2O.C7H6O2/c1-5-23(6-2,15-19-13-8-7-9-14-19)16-20(24)22-21-17(3)11-10-12-18(21)4;8-7(9)6-4-2-1-3-5-6/h7-14H,5-6,15- 16H2,1-4H3;1-5H,(H,8,9)
- Substance type: organic
- Physical state: Solid

Key result

Type:

pour density

Density:

0.385 g/cm³

Temp.:

26 °C

Remarks on result:

other: No other detail available

Key result

Type:

tap density

Density:

0.455 g/cm³

Temp.:

26 °C

Remarks on result:

other: No other detail available

Parameters	Details	Calculated Values (RESULT)
Pour Density of test substance (g/cm^3)	= m     v	0.3846 g/cm^3
Tap density of test substance (g/cm^3)	= m     v1	0.4545 g/cm^3

Conclusions:

The pour density and tap density for granular form of Denatonium benzoate is determine to be 0.3846 g/cm3 and 0.4545 g/cm3 respectively at temperature 26°C.

Executive summary:

The density of test substance Denatonium benzoate was determined following OECD guideline OECD 109. The pour density and tap density for granular form of Denatonium benzoate is determine to be 0.3846 g/cm3 and 0.4545 g/cm3 respectively at 26°C.

Reference 2

Endpoint:

density, other

Remarks:

Density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

24/08/2015- 25/08/2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Principles of method if other than guideline:

The density was determined for the test substance Denatonium benzoate (CAS No. 3734-33-6) by pour density method following the OECD Guideline 109 for density of solids and liquids and standard method recommended in the International Pharmacopoeia, fourth Edition, 2014.

GLP compliance:

no

Type of method:

other: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014

Specific details on test material used for the study:

- Name of test material (as cited in study report): Denatonium benzoate
- IUPAC NAme : benzyl({[(2,6-dimethylphenyl)carbamoyl]methyl})diethylazanium benzoate hydrate
- Molecular formula: C21H29N2O.C7H5O2
- Molecular weight: 446.58 g/mol
- Smiles : CC[N+](CC)(Cc1ccccc1)CC(=O)Nc2c(cccc2C)C.c1ccc(cc1)C(=O)[O-]
- InChI : 1S/C21H28N2O.C7H6O2/c1-5-23(6-2,15-19-13-8-7-9-14-19)16-20(24)22-21-17(3)11-10-12-18(21)4;8-7(9)6-4-2-1-3-5-6/h7-14H,5-6,15- 16H2,1-4H3;1-5H,(H,8,9)
- Substance type: organic
- Physical state: Solid

Key result

Type:

pour density

Density:

0.333 g/cm³

Temp.:

26 °C

Remarks on result:

other: No other detail available

Key result

Type:

tap density

Density:

0.4 g/cm³

Temp.:

26 °C

Remarks on result:

other: No other detail available

Parameters	Details	Calculated Values (RESULT)
Pour Density of test substance (g/cm^3)	= m     v	0.3333 g/cm^3
Tap density of test substance (g/cm^3)	= m     v1	0.4000 g/cm^3

Conclusions:

The pour density and tap density for powdered form of Denatonium benzoate is determine to be 0.3333 g/cm3 and 0.4000 g/cm3 respectively at 26°C.

Executive summary:

The density of test substance Denatonium benzoate was determined following OECD guideline OECD 109. The pour density and tap density for powdered form of Denatonium benzoate is determine to be 0.3333 g/cm3 and 0.4000 g/cm3 respectively at 26°C.

Description of key information

The density was determined for the test substance Denatonium benzoate (CAS No. 3734 -33 -6) by pour density method following the OECD Guideline 109 for density of solids and liquids and standard method recommended in the International Pharmacopoeia, fourth Edition, 2014.The pour density and tap density for granular form was determine to be 0.3846 g/cm³and  0.4545 g/cm³at 26°C.The pour density and tapped density for powdered form was determine to be 0.3333 g/cm³and  0.4000 g/cm³at 26°C.

Key value for chemical safety assessment

Relative density at 20C:

0.385

Additional information

The density was determined for the test substance Denatonium benzoate (CAS No. 3734 -33 -6) by pour density method following the OECD Guideline 109 for density of solids and liquids and standard method recommended in the International Pharmacopoeia, fourth Edition, 2014.The pour density and tap density for granular form was determine to be 0.3846 g/cm³and  0.4545 g/cm³at 26°C.The pour density and tapped density for powdered form was determine to be 0.3333 g/cm³and  0.4000 g/cm³at 26°C.

From other reliable sources it is concluded that density of Denatonium benzoate is 1.1256 g/cm3 at temperature 25 Deg C.