Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-733-7 | CAS number: 3590-84-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
No study is available for Tetraoctyltin however studies are available for other related compounds namely 2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-8-oxa-3 ,5-dithia-4-stannatetradecanoate (CAS: 57583-34-3) and 2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate (CAS: 15571-58-1). Furthermore computer predictions run using DEREK for windows program indicate that all organotin compounds are potential skin sensitizers. As a positive result reflects the worst case scenario for this endpoint it is considered justified to utilize read across to the "worst case" results for other organotin substances in this case.
Migrated from Short description of key information:
No study addressing teh skin sensitization potential is available for Tetraoctyltin however studies are available for other related compounds namely 2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-8-oxa-3 ,5-dithia-4-stannatetradecanoate (CAS: 57583-34-3) and 2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate (CAS: 15571-58-1). Furthermore computer predictions run using DEREK for windows program indicate that all organotin compounds are potential skin sensitizers. As a positive result reflects the worst case scenario for this endpoint it is considered justified to utilize read across to the "worst case" results for other organotin substances in this case.
Justification for classification or non-classification
The test substance is classified as a sensitizer using read across results based on a local lymph node assay that elicited a positive result in 2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-8-oxa-3 ,5-dithia-4-stannatetradecanoate (CAS: 57583-34-3).
2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-8-oxa-3 ,5-dithia-4-stannatetradecanoate (CAS: 57583-34-3) was found to be sensitising according to 67/548/EEC and should therefore be classified as R43 - May cause sensitisation by skin contact. Furthermore the substance is to be regarded as a Category 1 skin sensitizer in accordance with Regualtion (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
