Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-598-4 | CAS number: 3547-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Studies conducted specifically to evaluate reproductive toxicity were not available. However, two oral developmental studies and a 90-day oral repeated dose study are available. The 90-day dietary study indicated no adverse effects on male and female reproductive organs up to 2% in the diet (Powers, M.B., 1961). There were no effects on any of the cesarean parameters or maternal toxicity in rats up to 1000 mg/kg/day in a oral gavage developmental toxicity study (U.S. EPA, 1995).
Effects on developmental toxicity
Additional information
In a developmental toxicity study conducted with methods similar to OECD Guideline 414, Sprague- Dawley Crl:CD BR rats (24/group) were orally administered ethanol, 2 -(octylthio) at 0, 100, 300 or 1000 mg/kg bw/day during days 6 through 15 of gestation. There was no maternal toxicity that was considered treatment-related. Dosing had no effect on any of the cesarean parameters (e.g. mean numbers of corpora lutea, implantations, live fetuses, pre- and post-implantation losses). Therefore, for maternal toxicity, the NOEL was 1000 mg/kg bw/day. Minor treatment-related skeletal variations were limited to an increase, both in the number and percent of fetuses, as well as litters with 14th vestigial ribs at 1000 mg/kg bw/day when compared to controls. The NOEL for developmental toxicity was determined to be 300 mg/kg/day (US EPA, 1995).
In a second developmental toxicity study conducted with methods similar to OECD Guideline 414, female SPF rats (20/group) were treated with ethanol, 2 -(octylthio) via oral gavage during the 5th through 15th day of pregnancy at dose levels of 47, 187 amd 748 mg/kg bw/day. Results indicated food consumption was significantly reduced in all test groups, although no maternal or fetal parameters (e.g. index of dead and alive born fetuses, index of resorptions, average number of fetuses, sex relation, etc) were affected and no embryotoxic or teratogenic effects were observed. The NOELs for maternal and developmental toxicity was determined to be 748 mg/kg bw/day (International Bio-research Inc., 1977).
In conclusion, the weight of evidence indicates that 2 -(octylthio)ethanol is not a developmental toxicant. The lowest NOAEL for developmental toxicity is 300 mg/kg/day.
Justification for classification or non-classification
Based on the available developmental toxicity data on 2-(octylthiol)ethanol, no classification under DSD or GHS/CLP is warranted.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.