2-(propyloxy)ethanol

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1988

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was conducted according to guideline and/or standard method but there were no data on GLPs.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Methods for Measuring the Acute Toxicity of Effluents to Freshwater and Marine Organisms, EPA/600/4-85/013 March 1985.

Principles of method if other than guideline:

Not applicable

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-(propyloxy)ethanol

EC Number:

220-548-6

EC Name:

2-(propyloxy)ethanol

Cas Number:

2807-30-9

Molecular formula:

C5H12O2

IUPAC Name:

2-(propyloxy)ethanol

Details on test material:

Test material: Propyl CELLOSOLVE
Source: Union Carbide Corporation

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
No data

Sampling and analysis

Analytical monitoring:

not specified

Details on sampling:

No data

Test solutions

Vehicle:

not specified

Details on test solutions:

Dechlorinated Charleston municipal water was used in tests as dilution water and in experimental controls. This same water was used for
maintaining fathead minnow population. The incoming water was treated with activated carbon in a series of two 8-10 gallon filters yielding a
chlorine-free dilution water with a pH very close to 7.0. Total hardness of this water measured 40 to 60 mg/L as CaCO3. The carbon beds were changed as needed to maintain water quality.

Test organisms

Test organisms (species):

Pimephales promelas

Details on test organisms:

The test fish, fathead minnows, were obtained from Union Carbide's laboratory culturing program. Size of the minnows ranged from 1.5-3 cm. Any chemical treatment required to control or prevent disease was stopped at least five days prior to using the fish in tests.

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Post exposure observation period:

None

Test conditions

Hardness:

No data

Test temperature:

No data

pH:

No data

Dissolved oxygen:

No data

Salinity:

No data

Nominal and measured concentrations:

No data

Details on test conditions:

The definitive tests were conducted by EPA-ASTM procedures using 10 fathead minnows per test concentration in a total volume of 0.75 liters.
Temperature, fish survival, pH and dissolved oxygen levels were monitored during the test period of 96 hours. Minimal aeration was supplied when the dissolved oxygen was below about 4 mg/L.

Reference substance (positive control):

not specified

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 5 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Details on results:

No additional data

Results with reference substance (positive control):

No data

Reported statistics and error estimates:

None

Any other information on results incl. tables

Sublethal observations / clinical signs:

None

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified

Conclusions:

The 96h acute LC50 in fish is >5000 mg/L.

Executive summary:

96 hour Static definitive tests were conducted by EPA-ASTM procedures using 10 fathead minnows (Pimephales promelas) per test concentration in a total volume of 0.75 liter. Temperature, fish survival, pH and dissolved oxygen levels were monitored during the test period of 96 hours. Minimal aeration was supplied when the dissolved oxygen was below about 4 mg/L.

The 96h acute LC50 in fish was found to be >5000 mg/L.