2,2'-(vinylenedi-p-phenylene)bis[5-methylbenzoxazole]

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Remarks:

FB002 is one component of the read-across substance

Adequacy of study:

supporting study

Study period:

May from 2 to 21, 2019

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Justification for type of information:

Details on the read-across are available in section 13.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

Deviations:

yes

Remarks:

water flow continued until equilibrium was reached, as measured concentrations do not show a tendency of increasing values. However, concentrations of successive samples differ by more than ± 30% randomly, as measured values were around LOQ (0.2 ng/ml).

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

2014

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Version / remarks:

1998

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Water solubility:

0.226 µg/L

Conc. based on:

other: peak 1

Temp.:

20 °C

pH:

7.3 - 7.7

Water solubility:

0.218 µg/L

Conc. based on:

other: peak 2

Temp.:

20 °C

pH:

7.3 - 7.7

Water solubility:

0.183 µg/L

Conc. based on:

other: peak 3

Temp.:

20 °C

pH:

7.3 - 7.7

Details on results:

The measured concentration values varied around the limit of quantification (LOQ) of the analytical method. In the cases when concentrations were below LOQ, the concentration of LOQ derived from the calibration curve was used for calculations. The measured pH values were between 7.3 and 7.7. Flow rates of 25 and 12.5 ml/h were used.

Fluorescent Brightener 219 Mean solubility (ca. 25 ml/h) Mean solubility (ca. 12.5 ml/h) Mean solubility with 95 % c. i.
based on peak 1 0.22 µg/l 0.23 µg/l 0.226 ± 0.0261 µg/l
based on peak 2 0.22 µg/l 0.21 µg/l 0.218 ± 0.0235 µg/l
based on peak 3 0.19 µg/l 0.18 µg/l 0.183 ± 0.0119 µg/l

Conclusions:

Poorly soluble in water, ca. 0.2 µg/l at 20 ± 0.5 °C and pH 7.3-7.7.

Executive summary:

OECD guideline 105. Based on results of a preliminary test, the column elution method was used. 3 peaks, corresponding to the 3 main constituents were identified.

Test substance resulted as very poorly soluble, i.e. ca. 0.2 µg/l at 20 ± 0.5 °C and pH 7.3-7.7. Analytical method LOQ is 0.2 µg/l.

Description of key information

ca. 2.236E-06 mg/l at 25 °C.

Key value for chemical safety assessment

Water solubility:

0 mg/L

at the temperature of:

25 °C

Additional information

Prediction by EPISuite v4.11 tool.