Registration Dossier
Registration Dossier
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EC number: 218-320-6 | CAS number: 2116-84-9
Endpoint summary
Administrative data
Description of key information
The key acute oral toxicity study, conducted according to OECD TG 423, and in compliance with GLP, reports an LD50 value of >= 2000 mg/kg bw for 1,1,1,5,5,5-hexamethyl-3-phenyl-3-[(trimethylsilyl)oxy]trisiloxane.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The key acute oral toxicity study, conducted according to OECD TG 423, and in compliance with GLP, reports an LD50 value of >= 2000 mg/kg bw for 1,1,1,5,5,5-hexamethyl-3-phenyl-3-[(trimethylsilyl)oxy]trisiloxane.
Following a single oral administration of 2000 mg/kg bw of 1,1,1,5,5,5-hexamethyl-3-phenyl-3-[(trimethylsilyl)oxy]trisiloxane to 6 female rats, no mortality occurred during the 14-day observation period. No clinical signs of toxicity or changes to body weight gain were noted in any of the test animals. No abnormalities were observed at necropsy in any of the test animals. Body weights were recorded on days 1, 8 and 15. Clinical examinations were performed several times during the first 4 hours post-dosing, then once daily for the 14-day observation period. All animals were sacrificed at the end of the study period and necropsy was performed.
In the supporting study (Bayer, 1967, Rel 4), the test substance
(tris(trimethylsiloxy)phenylsilane) was administered to rats by oral
gavage at doses of 1000, 2500 and 5000 mg/kg bw/day. No animals died and
there were no unusual clinical observations. Therefore, in this study
the oral LD50 in rats was >5000 mg/kg bw/day.
Justification for classification or non-classification
Based on the available data for 1,1,1,5,5,5-hexamethyl-3-phenyl-3-[(trimethylsilyl)oxy]trisiloxane, no classification for acute toxicity is required according to Regulation (EC) No. 1272/2008.
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