Tetrabutylammonium hydroxide

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

GLP compliance:

no

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

1.518

Temp.:

25 °C

pH:

8

Remarks on result:

other: logKow was reported to be 1.5175 ± 0.0213

Details on results:

The Partition coefficient (Pow) of the test chemical was determined to be 1.5175 ± 0.0213 at 25°C

Table:

Test substance		K	Log k	Log Pow by Generalized Calibration Graph	Mean of Log Pow ± S.D.
Rt1	0.683	-0.2734	-0.5632	1.5024	1.5175±0.0213
Rt2	0.676	-0.2808	-0.5515	1.5325

Conclusions:

The partition coefficient (n-octanol/water) of test chemical was determined as per the HPLC method (OECD Guideline-117). The Log Pow value was determined to be 1.5175 ± 0.0213 at 25°C.

Executive summary:

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test solution was prepared by accurately measuring 4μL of test chemical and diluted with acetonitrile up to 10 ml. Thus, the test solution concentration was 392 mg/l. The pH of test substance was 8.0. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared. The reference substances were having Pow value ranging from 0.5 to 4.6. The Log Pow value was determined to be 1.5175 ± 0.0213 dimensionless at 25°C. On the basis of this value, test chemical can be considered to be hydrophilic in nature.

Description of key information

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test solution was prepared by accurately measuring 4μL of test chemical and diluted with acetonitrile up to 10 ml. Thus, the test solution concentration was 392 mg/l. The pH of test substance was 8.0. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared. The reference substances were having Pow value ranging from 0.5 to 4.6. The Log Pow value was determined to be 1.5175 ± 0.0213 dimensionless at 25°C. On the basis of this value, test chemical can be considered to be hydrophilic in nature.

Key value for chemical safety assessment

Log Kow (Log Pow):

1.517

at the temperature of:

25 °C

Additional information

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test solution was prepared by accurately measuring 4μL of test chemical and diluted with acetonitrile up to 10 ml. Thus, the test solution concentration was 392 mg/l. The pH of test substance was 8.0. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared. The reference substances were having Pow value ranging from 0.5 to 4.6. The Log Pow value was determined to be 1.5175 ± 0.0213 dimensionless at 25°C. On the basis of this value, test chemical can be considered to be hydrophilic in nature.