Registration Dossier
Registration Dossier
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EC number: 217-968-7 | CAS number: 2022-85-7
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-06-07 - 2004-07-19
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 27 July 1995.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- Flucytosine
- EC Number:
- 217-968-7
- EC Name:
- Flucytosine
- Cas Number:
- 2022-85-7
- Molecular formula:
- C4H4FN3O
- IUPAC Name:
- flucytosine
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- please refer to Test material information
Results and discussion
Water solubility
- Key result
- Water solubility:
- >= 11.5 - <= 11.7 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 3.8 g/L
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- >= 5.7 - <= 5.9
- Remarks on result:
- other: Mean concentration: 11.6 g/l at 20.0 ± 0.5ºC
- Remarks:
- Incubation duration, Temperature, and pH for each sample number are stated below
Any other information on results incl. tables
Preliminary test
The preliminary estimate of water solubility was 12.1 g/L.
Definitive test
The concentration (g/L) of test material in the sample solutions is shown in the following table:
Sample Number |
Time Shaken at ~ 30ºC (hours) |
Time Equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
1 |
24 |
24 |
11.7 |
5.7 |
2 |
48 |
24 |
11.7 |
5.8 |
3 |
72 |
24 |
11.5 |
5.9 |
Mean concentration: 11.6 g/l at 20.0 ± 0.5ºC
Range: 11.5 to 11.7 g/L
Validation
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 400 mg/L. This was satisfactory with a correlation coefficient of 1.000 being obtained.
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the test material has been determined to be 11.6 g/L of solution at 20.0 ± 0.5°C.
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