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EC number: 216-784-4 | CAS number: 1667-10-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 June 2016 to 08 June 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source: Provided by sposor
- Lot/batch No.of test material: 150701
- Expiration date of the lot/batch: 14 July 2017
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: - Storage conditions: Controlled room temperature (15-25 ºC, below 70 RH%), protected from humidity, under inert gas. - Water solubility:
- < 0.02 µg/L
- Conc. based on:
- test mat.
- Incubation duration:
- < 117 h
- Temp.:
- 20 °C
- pH:
- >= 4.95 - <= 5.03
- Remarks on result:
- other: LOQ tested
- Details on results:
- The test material was not detectable during the study. Therefore the water solubility is determined to be < 0.02 μg/mL (LOQ) at 20 °C ± 1 °C using the column elution method for the performance of the main test.
- Conclusions:
- Under the conditions of the study, the test material was not detectable during the study. Therefore the water solubility is determined to be < 0.02 μg/mL (LOQ) at 20 °C ± 1 °C using the column elution method.
- Executive summary:
The water solubility of the test material was determined using the column elution method in a GLP study conducted in accordance with the standardised guidelines OECD 105 and EU method A.6.
The column elution method was used to investigate the water solubi.lity of the test material at 20 ± 1 °C. 200 mg of test material was dissolved in 100 mL acetone, and this solution was added to approximately 40-50 g of inert support material (glass beads). The solvent was completely evaporated using a rotary evaporator. The dry support material was poured into the micro-column, filled with water. The system was then equilibrated for two hours. Then the flow through the column was started at a rate of 25 mL/h. The first five bed volume water was discarded to remove water-soluble impurities. After 68, 74, 92, 96 and 117 hours circulation, 0.4 mL samples were taken and injected directly. A second run was performed in a similar manner at about 12.5 mL/h flow rate. After 68, 74, 92, 96 and 117 hours circulation 0.4 mL water samples were taken and injected directly. pH of all samples was determined.
Under the conditions of the study, the test material was not detectable during the study. Therefore the water solubility is determined to be < 0.02 μg/mL (LOQ) at 20 °C ± 1 °C using the column elution method.
Reference
Description of key information
Under the conditions of the study, the test material was not detectable during the study. Therefore the water solubility is determined to be < 0.02 μg/mL (LOQ) at 20 °C ± 1 °C using the column elution method.
Key value for chemical safety assessment
- Water solubility:
- 0.2 µg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material was determined using the column elution method in a GLP study conducted in accordance with the standardised guidelines OECD 105 and EU method A.6. The study was assigned a reliability score of 1 in accordance with the criteria for assessing data quality set forth by Klimisch et al. (1997).
The column elution method was used to investigate the water solubi.lity of the test material at 20 ± 1 °C. 200 mg of test material was dissolved in 100 mL acetone, and this solution was added to approximately 40-50 g of inert support material (glass beads). The solvent was completely evaporated using a rotary evaporator. The dry support material was poured into the micro-column, filled with water. The system was then equilibrated for two hours. Then the flow through the column was started at a rate of 25 mL/h. The first five bed volume water was discarded to remove water-soluble impurities. After 68, 74, 92, 96 and 117 hours circulation, 0.4 mL samples were taken and injected directly. A second run was performed in a similar manner at about 12.5 mL/h flow rate. After 68, 74, 92, 96 and 117 hours circulation 0.4 mL water samples were taken and injected directly. pH of all samples was determined.
Under the conditions of the study, the test material was not detectable during the study. Therefore the water solubility is determined to be < 0.02 μg/mL (LOQ) at 20 °C ± 1 °C using the column elution method.
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