Registration Dossier
Registration Dossier
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EC number: 216-652-6 | CAS number: 1634-02-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- mouse
- Sex:
- not specified
- Route of administration:
- other: Intraperitoneal
- Vehicle:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- >= 2 350 mg/kg bw
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- TBUT has shown intraperitoneal LD50 as >2350mg/kg bw.
- Executive summary:
Intraperitoneal route of administration is seen as a very worse case scenario for toxicity testing. There is anecdotal evidence that the lethal dosage for oral administration is considered double compared to intraperitoneal administration. Therefore, the overall conclusion is that the substance can be considered for classification as non-hazardous for acute oral toxicity.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 350 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
