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Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

Sodium sulfate is not toxic to C. dubia in the long-term experiments. The LOEC for reproduction was 1329 mg/L, which was the lowest result obtained in this test. The NOEC (taken from a graph) is approx. 1109 mg/L.

The test was found to be valid with restrictions because the study was well conducted with standard guidelines and chemical analysis. No GLP no analytical certificates and no raw data were documented.

Key value for chemical safety assessment

Marine water invertebrates

Marine water invertebrates
Effect concentration:
1 109 mg/L

Additional information

Three-brood survival/reproduction bioassays( which lasted for 7 days) were performed with Ceriodaphnia dubia according to standard ASTM guidelines (Soucek, 2007). These tests were found reliable with restrictions, because the tests were not performed under GLP and no raw data were documented, they were well conducted according to standard guideline and with chemical analysis. The LOEC for reproduction was 1329 mg/L, which was the lowest result obtained in this test. The NOEC (taken from a graph) is approx. 1109 mg/L.

Long-term measurement of reproduction rate was performed as follows. Organisms were cultured according to US EPA methods with the only modification being that the culture water contained an elevated sodium sulfate concentration of 1000 mg SO4 2-/L. Cultures were initiated simultaneously using the same cohort of neonates produced by animals cultured in MHRW. Neonates to start a new generation were selected from animals that had produced at least three broods and had not reproduced on the previous day. Five generations were cultured in each treatment.

Sodium sulfate is not toxic to C. dubia in the long-term experiments. The LOEC for reproduction in MHRW was 1329 mg/L, which was the lowest result obtained in this test. The NOEC (taken from a graph) is approx. 1109 mg/L.

Over 5 generations reproduction was significantly lower in 1000 mg SO4 2-/L compared to the control.