Registration Dossier
Registration Dossier
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EC number: 214-192-0 | CAS number: 1112-55-6
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: assessment
Reference
Description of key information
No toxicokinetics studies are available for absorption of assessed substance. Based on its physicochemcial properties, and available toxicological studies together with QSAR, assessed substance is estimated to be likely absorbed following oral administration and a default value of complete (i.e., 100%) oral absorption is assumed for risk assessment. Absorption via the dermal route is considered to be low however a default value of 100% skin absorption is generally used unless molecular mass is above 500 and log P is outside the range [-1, 4]. The inhalation absorption can be assumed to be likely.
No experimental data on the distribution properties/metabolism/ excretion of assessed substance is available though there is limited data suggestive of metabolism and excretion. Accumulation in fatty tissue is expected to occur due to lipophilic substance (log P >0). QSAR Database indicated partitioning between the two tissues (brain/blood) at equilibrium is medium. And QSAR Database also predicted no metabolism of assessed substance by CYP2C9 and CYP2D6 that are the main cytochromes involved in Humans xenobiotics metabolism.
The assessed substance is considered to be excreted in the faeces due to the low water solubility.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
