Dibutyltin di(acetate)

Short-term toxicity to aquatic invertebrates

Description of key information

The following studies have been submitted to address the short-term toxicity to aquatic invertebrates endpoint:
Goodband & Mullee, 2010. ACUTE TOXICITY TO DAPHNIA MAGNA. Testing laboratory: Harlan Laboratories Ltd, Sharldow Business Park, London Road, Shardlow, Derbyshire, DE72 2GD, UK. Report no.: 3109 /0033 Owner company: Organo Tin REACH Consortium, c/o ReachCentrum, Avenue E. Van Nieuwenhuyse 6, B-1160 Brussels, BELGIUM.
The study was performed to assess the acute toxicity of the test item to Daphnia magna. The study was performed in compliance with GLP. The method followed that described in the OECD Guidelines for Testing of Chemicals (April 2004) No 202, "Daphnia sp, Acute Immobilisation Test" referenced as Method C.2 of Commission Regulation (EC) No. 440/2008. The study was assigned a reliability score of 1.
The acute toxicity of the test item to the freshwater invertebrate Daphnia magna has been investigated and, based on 0-Hour equivalent  concentrations as test item, gave a 48-Hour EC50 value of 1.4 mg/l with 95% confidence limits of 1.3   1.5 mg/l.  The No Observed Effect Concentration at 48 hours was 0.65 mg/l.
Steger-Hartmann, T. & Schmidt, M. (1998). Acute immobilization test of di-n-butyltin oxide (ZK 26385) with Daphnia magna. Testing laboratory: Schering AG, Experimentelle Toxikologie, D-13342 Berlin, Germany. Report no.: IC26. Owner company: Schering AG, Experimentelle Toxikologie, Berlin, Germany. Study number: TXST19980203. Report date: 1998-12-03.
Result: The EC50 for 48 hours for di-n-butyltin oxide was determined to be 2.0 mg/l based on Total organic Carbon (TOC) concentration analysis. The highest concentration with no effect was 1.1 mg/l. As the study was performed on a read-across substance, the study was assigned a reliability score of 2.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

1.4 mg/L

Additional information

Goodband & Mullee, 2010, has been performed in line with the appropriate guideline and to GLP and has been allocated a Klimsich score of 1. This study is considered to be the key study for this endpoint as it was conducted on the test material. A 48-Hour EC50 value of 1.4 mg/l with 95% confidence limits of 1.3 1.5 mg/l was determined.. The No Observed Effect Concentration at 48 hours was 0.65 mg/l.

Steger-Hartmann and Schmidt (1999) was performed in line with the appropriate guideline and to GLP but using dibutyltin oxide as the test material. The study has been allocated a Klimisch score of 2 and is included as a supporting study due to the fact that it is known that organotin ligand will hydrolyse to this form. The EC50 for 48 hours for di-n-butyltin oxide was determined to be 2.0 mg/l based on Total organic Carbon (TOC) concentration analysis. The highest concentration with no effect was 1.1 mg/l.