Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

skin irritation (OECD 404): not irritating

eye irritation (OECD 405): not irritating

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation/corrosion

The read-across substance Niacin bound Chromium (ChromeMate CM-100M) was investigated in an acute dermal irritation study performed equivalent to OECD 404 and GLP (Shara, 2005). The test substance dissolved in corn oil was applied to the shaved skin of one male and two New Zealand Albino rabbits under semiocclusive conditions for 4 hours. 1 h after the application, very-slight erythema was observed at all three treated sites. The overall incidence and severity of irritation decreased with time. All animals were free from dermal irritation within 48 h. Apart from the dermal irritation noted, all animals appeared active and healthy and with no other signs of gross toxicity. Therefore, the source substance was considered to be not irritating to the skin under the conditions of this test. In addition, an acute dermal toxicity study performed with the Acetic acid, chromium salt, basic does not indicate skin irritation up to the limit dose level of 2000 mg/kg body weight (Seguier, 2008).

Eye irritation/corrosion

A HET-CAM was performed with Acetic acid, chromium salt, basic which revealed no corrosive effects (Paulus and Rudolf, 2008).

In addition, Niacin bound chromium (ChromeMate CM-100M) was investigated in an acute eye irritation study performed equivalent to OECD 405 and GLP (Shara, 2005). 0.1 mL of the substance dissolved in water was applied to the conjuctival sac of one 1 male and two female rabbits. The untreated eye served as control. The eyes were investigated 1, 24, 48, and 72 h post-installation. No corneal opacity or iritis was observed in any treated eye during the study. One hour following test substance instillation, all treated eyes exhibited conjunctivitis. All animals were free of ocular irritation within 24 h. Apart from the eye irritation noted, all animals appeared active and healthy and with no other signs of gross toxicity. Therefore, the source substance was considered to be not irritating to the eye under the conditions of this test.

Justification for selection of skin irritation / corrosion endpoint:

Hazard assessment is conducted by means of read-across from a structural analogue/surrogate. The selected study is the most adequate and reliable study based on the identified similarities in structure and intrinsic properties between source and target substance and overall quality assessment (refer to the endpoint discussion for further details).

Justification for selection of eye irritation endpoint:

Hazard assessment is conducted by means of read-across from a structural analogue/surrogate. The selected study is the most adequate and reliable study based on the identified similarities in structure and intrinsic properties between source and target substance and overall quality assessment (refer to the endpoint discussion for further details).

Justification for classification or non-classification

The available data on the skin and eye irritation do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and is therefore conclusive but not sufficient for classification.