Registration Dossier
Registration Dossier
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EC number: 213-600-4 | CAS number: 993-00-0
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Biodegradation in water: screening tests: Not readily biodegradable: 0% (inorganic carbon analysis) in 28 days (OECD 310) for read-across substance trimethylsilanol.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
No data are available for the submission substance, chloro(methyl)silane. However, chloro(methyl)silane hydrolyses very rapidly in contact with water to give methylsilanol and hydrogen chloride. A reliable study conducted according to an appropriate test protocol (OECD 310), and in compliance with GLP is available for trimethylsilanol, which is a close structural analogue of methylsilanol. This is selected as the key study. Biodegradation is not relevant for hydrogen chloride as it is inorganic.
The use of such read-across is supported by evidence that within a category of small molecule silicon-dominated organosilicon compounds, without reactive functional groups in the side chain, there is no evidence of any significant biodegradation in ready biodegradation tests (Data gap filling report for ready biodegradability of silicon-dominated substances PFA.151.004.022A).
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