Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-427-4 | CAS number: 947-42-2
Endpoint summary
Administrative data
Description of key information
No effects were noted in the key oral and dermal acute toxicity studies and the LD50 in both was greater than 2000 mg/kg, the highest dose tested.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
An acute oral toxicity study was performed in rats according to OECD Test Guideline 401 and in compliance with GLP (Hazelton,1987a). An acute dermal toxicity study was performed in rats according to OECD Test Guideline 402 and in compliance with GLP (Hazelton, 1987b).
There were no remarkable findings or mortalities in either the key oral or dermal acute toxicity studies with diphenylsilanediol. Both studies identified the LD50 to be greater than 2000 mg/kg, the highest dose tested.
Justification for selection of acute toxicity – oral endpoint
Study was conducted in accordance with an appropriate guideline and in compliance with GLP.
Justification for selection of acute toxicity – dermal endpoint
Study was conducted in accordance with an appropriate guideline and in compliance with GLP.
Justification for classification or non-classification
Based on the available data diphenylsilanediol does not require classification for acute toxicity according to Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
