Registration Dossier
Registration Dossier
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EC number: 213-026-4 | CAS number: 917-54-4
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Lithium hydroxide monohydrate was tested for its long-term toxicity to fish in a study performed according to OECD 210 guideline. The LOEC and NOEC values obtained were 24.35 and 17.35 mg/L respectively (based on measured concentrations).
Based on this study result, the calculated LOEC and NOEC values for methyllithium are 12.8 mg/L and 9.1 mg/L.
Key value for chemical safety assessment
Additional information
Long-term toxicity to fish
The purpose of the performed study was to evaluate the chronic toxicity of the test item lithium hydroxide monohydrate to early life stages (embryo, larvae and juveniles) of fish (Danio rerio) according to the OECD 210 guideline. Around 40 eggs per treatment / concentration level (2 replicates per treatment) were exposed in a semi static test to aqueous test media containing the test item for 34 days at a range of concentrations (based on a preliminary study) under defined conditions. Results showed that lithium hydroxide monohydrate had significant lethal effect on early life stages of Zebrafish (Danio rerio) at a concentration level of 24.35 mg/L (measured concentration). The observed effect was associated with larval/juvenile stages, but no significant effect was observed during the embryonic stage.
No significant sub lethal effects (hatching of the larvae, body weight, body length, deformities and abnormal behaviour) were observed in any concentration tested.
The following endpoints (34 days LOEC and NOEC) were determined in the study:
LOEC of 24.35 mg test item/L
NOEC of 17.35 mg test item/L
The NOEC result does not lead to classification and labelling of lithium hydroxide for long-term aquatic toxicity (fish) according to Regulation (EC) No. 1272/2008 (CLP) and Directive 67/548/EC (DSD).
The following LOEC and NOEC values were calculated for methyllithium:
LOEC of 12.8 mg/L
NOEC of 9.1 mg/L
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