Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-681-0 | CAS number: 685-63-2
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.038 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.38 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.004 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- no emission to STP expected
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.448 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.045 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no exposure of soil expected
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Due the physical nature of hexafluoro-1,3-butadiene and due to the difficulty to test it meaningfully, no experimental aquatic results are available. Instead, QSAR methods have been used to estimate the acute toxicity of the substance to the aquatic organisms. The effect concentrations of hexafluoro-1,3 -butadiene were estimated using ECOSAR (v1.11). The experimental log Kow value of 2.24 was used for the predictions. All acute toxicity calculations are reliable, validated and fall within the applicability domain of the QSARs. The lowest value for freshwater species is calculated in algae (96-h EC50 = 38 mg/l).
Conclusion on classification
According to Regulation (EC) No. 1272/2008 for the Classification, Labelling and Packaging of Substances and Mixtures (CLP), results of validated structure activity relationships and expert judgment may also be taken into account where appropriate with regard to classification and labelling of
substances. The aquatic effect concentrations of hexafluoro-1,3 -butadiene estimated using ECOSAR (v1.11) are between 10 and 100 mg/L (toxicity to fish, daphnia and green algae are 81, 41 and 38 mg/L, respectively) and therefore hexafluoro-1,3 -butadiene is to be classified as harmful to the aquatic environment, Category Chronic 3; H412 (Harmful to aquatic life with long lasting effects).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
