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REACH

2-hydroxyethanesulphonic acid, compound with 4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine] (2:1)

EC number: 211-533-5 | CAS number: 659-40-5

Life Cycle description
Uses advised against

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

july 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

not specified

Type of method:

flask method

Specific details on test material used for the study:

Hexamidine di isethionate batch 42964

Key result

Water solubility:

48.2 g/L

Temp.:

20 °C

pH:

7.3

Details on results:

see tables below

day 1

concentration (g/100ml)	g/L	A
0.08212	0.008212	0.401
0.10379	0.010379	0.503
0.12511	0.012511	0.598
0.1522	0.01522	0.736

Day 1

	Absorbance	Slope	Ordinate	Concentration (g/L)	Mean (g/L)	coefficient of variation (%)
E1	0.469	47.5793	0.0085	48.3921	48.5497	1.50
E2	0.472	47.5793	0.0085	48.7073	48.5497	1.50
E3	0.480	47.5793	0.0085	49.5480	48.5497	1.50
E4	0.459	47.5793	0.0085	47.3412	48.5497	1.50
E5	0.474	47.5793	0.0085	48.9175	48.5497	1.50
E6	0.469	47.5793	0.0085	48.3921	48.5497	1.50

Day 2

concentration (g/100ml)

g/L

0.0847

0.00847

0.398

0.1043

0.01043

0.507

0.1207

0.01207

0.586

0.1576

0.01576

0.710

Day 3

Concentration (g/100ml)	g/L	A
0.083	0.0083	0.38
0.1029	0.01029	0.504
0.1222	0.01222	0.572
0.1538	0.01538	0.737

Day 3

	Absorbance	Slope	Ordinate	Concentration (g/L)	Mean (g/L)	coefficient of variation (%)
E1	0.469	49.1931	-0.0198	49.6825	49.5301	1.33
E2	0.462	49.1931	-0.0198	48.9710	49.5301	1.33
E3	0.468	49.1931	-0.0198	49.5809	49.5301	1.33
E4	0.479	49.1931	-0.0198	50.6989	49.5301	1.33
E5	0.461	49.1931	-0.0198	48.8694	49.5301	1.33
E6	0.466	49.1931	-0.0198	49.3776	49.5301	1.33

Conclusions:

the concentrations measured in at least the two last vessels do not differ by more than 15%, the test is satisfactory.
results:
solubility in water = 48.2g/L at 20°C

Executive summary:

solubility in water = 48.2g/L at 20°C

pH=7.3

precision=3.8% (mesured at 24h, 48h and 72h)

Description of key information

water solubility = 48.2g/L at 20°C

Key value for chemical safety assessment

Water solubility:: 48.2 g/L
at the temperature of:: 20 °C

Additional information

pH=7.3

precision=3.8% (mesured at 24h, 48h and 72h)

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