Registration Dossier
Registration Dossier
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EC number: 210-817-6 | CAS number: 623-84-7
Endpoint summary
Administrative data
Description of key information
GLP-studies according to OECD guidelines 401, 402 and 403 are available for PGDA. In addition, supporting studies (non-GLP) equivalent to OECD guidelines 401, 402 and 403 are available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 2 170 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Oral: in a GLP study conducted according to OECD guideline 401 no mortality was observed in rats up to the limit dose of 5000 mg/kg bw. This is supported by the results of 3 non-GLP studies reporting LD50s of 12.3 ml/kg bw and 14000 mg/kg bw in rats and 4000 mg/kg bw in guinea pigs.
Dermal: in a GLP-study according to OECD guideline 402 no mortality was observed in rabbits up to the limit dose of 2000 mg/kg bw. This is supported by the results of a non-GLP study reporting an LD50 greater than 16 ml/kg bw in rabbits.
Inhalation: in a GLP-study according to OECD guideline 403 no mortality was observed in rats after 6 hours exposure to 129 ppm PGDA which was the highest attainable vapor concentration. In a supporting study (non-GLP) no mortality was observed in rats after 8 hours exposure to 332 ppm (2.17 mg/l) PGDA.
Justification for classification or non-classification
LD50 values for oral and dermal route are greater than 2000 mg/kg/bw and no mortality has been observed after inhalation exposure to PGDA up to the highest dose tested. According to the EU criteria for classification and labeling, PGDA is not classified for acute toxicity for any route of exposure.
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