Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-519-6 | CAS number: 617-52-7
Water solubility
Administrative data
Link to relevant study record(s)
Description of key information
Very or „highly soluble“
Key value for chemical safety assessment
- Water solubility:
- 35.1 g/L
- at the temperature of:
- 20 °C
Additional information
- FAO Food & Agriculture Organization of the UN (2000). Appendix 2. Parameters of pesticides that influence processes in the soil. In FAO Information Division Editorial Group, ed, FAO Pesticide Disposal Series 8. Assessing Soil Contamination. A Reference Manual. Self-published, Rome, Italy. Available at http://www.fao.org/docrep/003/X2570E/X2570E06.htm (Accessed July 29, 2013).
- Klimisch HJ, Andreae M, Tillmann U (1997). A Systematic Approach for Evaluating the Quality of Experimental Toxicological and Ecotoxicological Data. DOI 10.1006/rtph.1996.1076 PMID 9056496 Regul Toxicol Pharmacol 25:1-5.
- Walker JA (2014). DMI: Determination of Water Solubility and Flammability (Solids). Harlan Laboratories Ltd., Shardlow Business Park, Shardlow, Derbyshire, DE72 2GD, U.K. Study report no. 41400265. Report date: 2014-04-19
The water solubility of the submission item Dimethyl itaconate (CAS 617-52-7) was investigated in a GLP-compliant study (Walker 2014, Harlan Laboratories Report no. 41400265) using the flask method according to the OECD TG 105 (1995) and EU A.6 (Commission Regulation (EC) No 440/2008) protocols. The experiment can be considered relevant and adequate for the endpoint. Therefore it is deemed conclusive and was rated „reliable without restrictions“, i.e. “Klimisch 1” according to the scale of Klimisch et al. (1997).
The test system consisted of purified (reverse osmosis) water. After stirring 24, 48 and 72 h at 30 °C followed by 24 h equilibration at 20.0 ± 0.5 °C, the concentration of test item in the sample solutions was quantified by gas chromatography (GC).
The water solubility was determined to be 35.1 g/L, calculated as the arithmetic mean of three replicates (range 34.8 to 35.5 g/L, standard deviation: ± 1.1 %). According to a scheme (FAO 2000) this result indicates that the submission item should be considered „highly soluble“.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
