Registration Dossier
Registration Dossier
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EC number: 210-259-3 | CAS number: 611-20-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 10 - June 19, 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- solubility dependance with pH included
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Principles of method if other than guideline:
- Solubility in buffered solutions also determined.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 20 g/L
- Temp.:
- 25 °C
- pH:
- 4.4
- Remarks on result:
- other: pure water; relative standard deviation 0.71%
- Water solubility:
- 19 g/L
- Temp.:
- 25 °C
- pH:
- 5
- Remarks on result:
- other: pH 5.0 buffer; relative standard deviation 2.3%
- Water solubility:
- 31 g/L
- Temp.:
- 25 °C
- pH:
- 6.8
- Remarks on result:
- other: pH 9.0 buffer; relative standard deviation 1%
- Conclusions:
- The solubility of the test substance in pure water was determined to be 20 g/L at 25°C.
The study is considered to be adequate and reliable.
Reference
No time dependance in the solubility was observed; reported solubility is average of all 3 experiments. Comparison of the sample solution HPLC retention times with the reference sample indicated no alteration during the course of the experiment.
Description of key information
20 g/L at 25°C, OECD 105, shake flask, Khot 2010
Key value for chemical safety assessment
- Water solubility:
- 20 g/L
- at the temperature of:
- 25 °C
Additional information
Only one study is available which measures the water solubility of the substance. This study is considered to be adequate and reliable.
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