Registration Dossier
Registration Dossier
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EC number: 209-264-3 | CAS number: 563-80-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A pre-GLP, static, limit study and a modern OECD 203 flow-through study conducted according to GLP.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Two fish studies are available for Methyl Isopropyl Ketone (MIPK). The first study was a pre-GLP study conducted as a limit test at a nominal 100 mg/L concentration under static, non-renewal conditions. In this study 50% mortality did not occur therefore the LC50 was reported as >100 mg/L. Due to concerns for volatility of the test substance, a recent OECD 203 study was conducted using a flow-through system with multiple concentrations up to 100 mg/L nominal. Some losses of the test substance occured during the study and the mean measured concentration for the highest exposure was 68 mg/L. No mortality was observed in this study therefore the NOEC was 68 mg/L and the LC50 was > 68 mg/L, the highest concentration tested. Based upon a weight of evidence from these two studies it is believed that the LC50 for fish is ≥ 100 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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