Registration Dossier
Registration Dossier
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EC number: 208-970-9 | CAS number: 549-56-4
Endpoint summary
Administrative data
Description of key information
The LD50 for rats after oral application is 455.8 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: There are no details on the method available.
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- There are no details on the method available.
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 455.8 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no further information available
- Interpretation of results:
- harmful
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The LD50 for rats is 455.8 mg/kg bw.
- Executive summary:
The acute toxicity of quinine sulphate was tested on rats after oral application. From the study it is shown, that the LD50 of quinine sulphate is 455.8 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 455.8 mg/kg bw
- Quality of whole database:
- There are no details on the method available.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The acute toxicity was tested on rats via oral route. From the study it is shown, that the LD50 is 455.8 mg/kg bw. It is considered as harmful according to EU criteria.
Justification for classification or non-classification
The LD50 of quinine sulphate of rats after oral application is 455.8 mg/kg bw. According to CLP 1272/2008 criteria for oral application, LD50 > 300 mg/kg bw and < 2000 mg/kg bw, quinine sulphate is considered as harmful, if swallowed and has to be classified in category 4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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