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EC number: 207-975-3 | CAS number: 503-74-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 29.3 µg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.293 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 2.93 µg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 22.4 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 117.3 µg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 11.7 µg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 6.25 µg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Deduction of PNECs is based on the Guidance Document "Guidance on information requirements and chemical safety assessment - Chapter R.10: Characterisation of dose[concentration]-response for environment" (TGD R.10) published by the European Chemicals Agency, 2008.
PNECs sediment and soil are derived using the equilibrium partitioning method. Values of Koc and Henry's Law constant are taken from the respective sections of IUCLID (Sect. 5.4.1 and Sect. 5.4.2). Estimates of Koc are calculated with the program KOCWIN v2.00 within US EPA EPI Suite v4.10 (GUBDH, 2012). Henry's Law constant was experimentally determined (Khan, 1992)
PNEC aqua (freshwater)
L(E)C50 values were determined using data from supporting substances. Data are available for all three trophic levels.
Valeric acid Isobutyric acid Conversion to Isovaleric acid
Short-term toxicity to fish 77 mg/L 77 mg/L
Short-term toxicity to aquatic invertebrates 51.25 mg/L 59.4 mg/L
Toxicity to aquatic algae and cyanobacteria 29.3 mg/L 29.3 mg/L
The lowest value (29.3 mg/L) was taken for derivation of PNECs aqua.
PNEC sediment (freshwater)
According to chapter R.10.5.2.1 of TGD R.10, the PNEC sediment can provisionally be calculated in the absence of data for sediment-dwelling organisms using the equilibrium partitioning method (EPM).
PNEC derivation following procedures of TGD R.10 and R.16:
PNEC aqua (freshwater): 29.3 µg/L,
Koc: 4.022 (US EPA EPI Suite estimate, program KOCWIN v2.00, Koc estimate from lMCI; see IUCLID Sect. 5.4.1);
The PNEC sediment (freshwater) was calculated to 25.5 µg/kg ww. This value was converted to dry weight (conversion factor of 4.6) resulting in a PNEC sediment (freshwater) of 117.3 µg/kg sediment dw.
PNEC sediment (marine water)
According to chapter R.10.5.2.1 of TGD R.10, the PNEC sediment can provisionally be calculated in the absence of data for sediment-dwelling organisms using the equilibrium partitioning method (EPM).
PNEC derivation following procedures of TGD R.10 and R.16:
PNEC aqua (marine water): 2.93 µg/L,
Koc: 4.022 (US EPA EPI Suite estimate, program KOCWIN v2.00, Koc estimate from MCI; see IUCLID Sect. 5.4.1);
The PNEC sediment (marine water) was calculated to 2.55 µg/kg ww. This value was converted to dry weight (conversion factor of 4.6) resulting in a PNEC sediment (marine water) of 11.7 µg/kg sediment dw.
PNEC soil
According tochapter R.10.6.1 of TGD R.10, the PNEC soil can provisionally be calculated in the absence of data for soil organisms using the equilibrium partitioning method (EPM).
PNEC derivation following procedures of TGD R.10 and R.16:
PNEC water (freshwater): 29.3 µg/L,
Koc: 4.022 (US EPA EPI Suite estimate, program KOCWIN v2.00, Koc estimate from MCI; IUCLID Sect. 5.4.1),
HLC: 0.0844 Pa*m³/mol (Khan 1992; IUCLID Sect. 5.4.2);
The PNEC soil was calculated to 5.53 µg/kg ww. This value was converted to dry weight (conversion factor of 1.13) resulting in a PNEC soil of 6.25 µg/kg soil dw.
Secondary poisoning
Isovaleric acid is readily biodegradable. Calculated BCF values are low (3.16 and 2.11 L/kg - calculated with the programs US EPA EPI Suite and US EPA TEST, respectively). Combined data indicate a low potential for bioaccumulation. There is no concern about toxic effects resulting from exposure via the food chain.
Conclusion on classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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