4-(phenylazo)benzene-1,3-diamine

Density

Link to relevant study record(s)

Reference

Endpoint:

density

Remarks:

density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

14-04-2017 – 14-04-2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Principles of method if other than guideline:

Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014
Pour Density: It is the ratio of known weight of test item and its volume in graduated glass cylinder.
Tap Density: It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder.

GLP compliance:

no

Type of method:

pycnometer method

Key result

Type:

pour density

Density:

0.421 g/cm³

Temp.:

29.1 °C

Key result

Type:

tap density

Density:

0.541 g/cm³

Temp.:

29.1 °C

FOR SOLIDS:
By Pour Density and Tapped Density Method:

Method Details		Observations		Remarks if, any
Guideline	OECD 109	1^stReading	2^ndReading	-
Method	Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014	-
Principle of method	Pour Density:It is the ratio of known weight of test item and its volume in graduated glass cylinder. Tap Density:It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder.	-
Test temperature (°C)	-	28.6°C	29.7°C
Atmospheric pressure (in hPa)		968.8	968.5
Weight of test item(m)		20.005	20.001
Volume of measuring cylinder; readability in g		50 ml;1 ml	50 ml;1 ml
Volume of test item without tapping (V)		48	47
Volume of test item after tapping ( V1)	After 10 tapping	44	45
	After 50 tapping	40	40
	After 100 tapping	36	38
	After 250 tapping	36	38
	After 500 tapping	-	-
	After 750 Tapping	-	-

*ρat=density of air at 27°C and 760 mm Hg pressure= 0.001168 g/cm³
**Density of water referred from the Table 1 of the IS method.

CALCULATIONS:

Parameters	Details	Calculated values		Average Density
		1st Calculation	2nd Calculation
Pour Density of test Item (g/cm³)	=m   V	0.4167	0.4255	0.4211
Tap density of test Item (g/cm³)	=m   V1	0.5556	0.5263	0.5410

Conclusions:

The density of test item 4-(phenylazo)benzene-1,3-diamine (CAS No. 495-54-5) was determined following OECD Guideline 109 and according to the The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of test item was found to be 0.4211 g/cm³ and 0.5410 g/cm³at 29.1°C and 968.6 hPa.

Executive summary:

The density of Test item 4-(phenylazo)benzene-1,3-diamine (CAS No. 495-54-5 ) was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.The mean pour density and tapped density of the test item was found to be 0.4211 g/cm³ and 0.5410 g/cm³at 29.1°C

and 968.6 hPa.

Description of key information

The density of test item 4-(phenylazo)benzene-1,3-diamine (CAS No. 495-54-5) was determined following OECD Guideline 109 and according to the The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of test item was found to be 0.4211 g/cm³ and 0.5410 g/cm³at 29.1°C and 968.6 hPa.

Key value for chemical safety assessment

Relative density at 20C:

0.421

Additional information

The density of Test item 4-(phenylazo)benzene-1,3-diamine (CAS No. 495-54-5 ) was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.The mean pour density and tapped density of the test item was found to be 0.4211 g/cm³ and 0.5410 g/cm³at 29.1°C and 968.6 hPa.

Supporting data from reliable handbook source (SAX handbook) the density of 4-(Phenylazo)benzene-1,3-diamine is determined as 1.139.

As the data from lab has K1 reliability and the test was performed using OECD guidelines, thus pour density value is considered as key value for the chemical safety assessment.