Registration Dossier
Registration Dossier
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EC number: 206-996-5 | CAS number: 420-46-2
Carcinogenicity
Administrative data
Description of key information
Rats were dosed five days per week for one year by gavage at a dose level of 300 mg/kg body weight. HFC-143a was dissolved in corn oil. They were held for an additional year and sacrificed. No treatment related tumors were found.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 300 mg/kg bw/day
Justification for classification or non-classification
HFC-143a did not show a carcinogenic response.
Additional information
Test article (HFC-143a) did not cause a carcinogenic response in this screening study. (Ref. Longstaff, E., Robinson, M., Bradbrook, C., Styles, JA., and Purchase, IFH., (1984). Genotoxicity and Carcinogenicity of fluorocarbons: Assessment by short-term in vitro tests and chronic exposures in rats. Toxicol. Appl. Pharmacol. 72, 15 -31.
Carcinogenicity: via oral route (target organ): other: all gross lesions and masses
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