Registration Dossier
Registration Dossier
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EC number: 206-662-9 | CAS number: 364-62-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Metoclopramide was shown to be potentially mutagenic and clastogenic in cultured rodent and human cells in contrast to procainamide, another benzamide drug. Mutations occurred in V79 cells (Martelli et al, 1995; Mereto et al, 1995). DNA breaks, inhibition of DNA repair and micronuclei formation in human peripheral blood lymphocytes have been demonstrated with metoclopramide. Doses used were approximately 100 times higher than therapeutic doses, thus it may be considered as a weak promoter (Lybak & Pero, 1991; Mereto et al, 1995; Martelli et al, 1995).
Metoclopramide. POISINDEX® System: Klasco RK: POISINDEX® System. Truven Health Analytics, Greenwood Village, Colorado.
Justification for classification or non-classification
Available data are inconclusive for a reliable assessment of germ cell mutagenicity of metoclopramide.
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