Registration Dossier
Registration Dossier
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EC number: 205-594-7 | CAS number: 143-24-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitasation potential was assessed based on analogue approach using ethoxymethoxy diethylene glycol (EMDE) and 2 -methoxyethanol (2-ME) as source chemicals.
The underlying scientific rationales are based on the structural similarity and metabolic consideration.
- EMDE is structurally related to the target chemical, exhibiting same chemical functional groups (ethylene glycol chain, methoxy moiety as well as the structural feature to be metabolized to 2-Methoxyethanol and 2-Methoxyacetic acid).
- 2-ME is the metabolite of tetraglyme.
Considering that the source chemicals comprises the structurally related substance (EMDE) and the presumed metabolites (2 -ME), it can be assumed that the major events leading to skin sensitization are well covered. Neither EMDE nor 2 -ME exhibited significant sensitization potential. Likewise, tetraglyme is considered to be a non skin sensitizer.
Migrated from Short description of key information:
The skin sensitization potential of tetraglyme can reliably derived based on the read-across approach and is considered to be low. No classification is warranted.
Justification for selection of skin sensitisation endpoint:
Two studies are proposed to be used as weight of evidence.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
There are no respiratory sensitization properties of the substance known in literature. Beyond this there is no hint of any sensitization property of the source chemicals of EMDE or 2 -ME for the analogue approach. Therefore, it is concluded that the subsance is not a respiratory sensitizer.
Migrated from Short description of key information:
It is concluded that the subsance is not a respiratory sensitizer based on the available informaion.
Justification for classification or non-classification
No classification is warranted for tetraglyme based on the read-across approach and the available information.
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