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Diss Factsheets
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EC number: 205-503-0 | CAS number: 141-82-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Testing is not considered necessary in view of assessment of being readily biodegradable. Normally, it is difficult to justify not performing this test as it is so important for the environmental assessment. However, in view of the rapid biodegradation of oxalic acid and succinic acid and the use of carboxylic acids as positive control substances, it is considered in this case unnecessary to perform a test on malonic acid.
- Principles of method if other than guideline:
- Assessment of biodegradation using grouping approach with short-chained dicarboxylic acids and QSAR modelling
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Test performance:
- Modelled using EPISuite, published by US EPA
- Details on results:
- Output of EPISuite:Probability of Rapid Biodegradation (BIOWIN v4.10): Biowin1 (Linear Model) : 0.8434 Biowin2 (Non-Linear Model) : 0.9436 Expert Survey Biodegradation Results: Biowin3 (Ultimate Survey Model): 3.6984 (days-weeks ) Biowin4 (Primary Survey Model) : 4.4687 (hours-days ) MITI Biodegradation Probability: Biowin5 (MITI Linear Model) : 0.8143 Biowin6 (MITI Non-Linear Model): 0.9020 Anaerobic Biodegradation Probability: Biowin7 (Anaerobic Linear Model): 1.2356 Ready Biodegradability Prediction: YES
- Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- readily biodegradable
- Conclusions:
- It is concluded that the substance is readily biodegradable and would fulfil the 10-day window criteria. This conclusion is based on review of similar low molecular weight dicarboxylic acids, including oxalic and succinic acids as well as modelling methods.
- Executive summary:
The grouping approach is considered valid in terms of assessment of environmental fate and effects
Reference
Description of key information
In view of the rapid biodegradation of oxalic acid and succinic acid and the use of carboxylic acids as positive control substances, it is considered in this case unnecessary to perform a test on malonic acid. Modelling has also been undertaken. Malonic acid occurs in nature and is formed and consumed during cellular metabolic processes.
Output of EPISuite:
Probability of Rapid Biodegradation (BIOWIN v4.10):
Biowin1 (Linear Model) : 0.8434
Biowin2 (Non-Linear Model) : 0.9436
Expert Survey Biodegradation Results:
Biowin3 (Ultimate Survey Model): 3.6984 (days-weeks )
Biowin4 (Primary Survey Model) : 4.4687 (hours-days )
MITI Biodegradation Probability:
Biowin5 (MITI Linear Model) : 0.8143
Biowin6 (MITI Non-Linear Model): 0.9020
Anaerobic Biodegradation Probability:
Biowin7 (Anaerobic Linear Model): 1.2356
Ready Biodegradability Prediction: YES
It is concluded that the substance is readily biodegradable and would fulfil the 10-day window criteria. This conclusion is based on review of similar low molecular weight dicarboxylic acids, including oxalic and succinic acids as well as modelling methods.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.