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EC number: 205-459-2 | CAS number: 141-12-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 27 October - 25 November 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study meets Test Guideline 301D requirements
- Justification for type of information:
- Read-across from substance nerol (see the document provided in section 13 for the justification).
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- reference to other study
- Parameter:
- % degradation (O2 consumption)
- Value:
- 90
- Sampling time:
- 28 d
- Details on results:
- Initial test material concentration: 2 mg/L
- Theoretical oxygen demand (ThOD) = 2.9 mg/mg
- % biodegradation on Day 2: > 10 %
- % biodegradation on Day 7: > 60 %
- % biodegradation on Day 28 = 90 % - Results with reference substance:
- - Theoretical oxygen demand (ThOD) = 0.8 mg/mg
- % biodegradation on Day 7: > 60 %
- % biodegradation on Day 14 = 78 % - Validity criteria fulfilled:
- yes
- Remarks:
- endogenous respiration at Day 28 was 1.1 mg/L; differences of the replicate values at Day 28 were < 20%; degradation in reference material was 78 % at Day 14; O2 concentration during the test was > 0.5 mg/L
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Under the test conditions, nerol was readily biodegradable.
- Executive summary:
In a ready biodegradation study performed according to OECD Guideline 301 D and GLP, nerol was tested at concentrations of 2 mg/L and the inoculum was river water (near to a domestic wastewater treatment plant, 3 km upstream). The degradation of the test material was assessed by the determination of the oxygen consumption. The test treatments, inoculum blank, and reference (sodium acetate) were measured in duplicates.
At 2 mg/L, greater than 10% of degradation was reached by Day 2 and greater than 60% of biodegradation was reached by Day 7. Hence, the test material met the 14 day window requirement for ready biodegradability. On Day 28, the biodegradation was 90%.
The reference material, sodium acetate, reached greater than 60% of biodegradation on Day 7. Nerol was considered to be non-toxic to micro-organisms as inhibition of the endogenous respiration of the inoculum was not detected during the test. Hence, it met the validity criteria for reference material and toxicity control. The endogenous respiration at Day 28 was 1.1 mg/L and oxygen concentration during the test was greater than 0.5 mg/L.
Therefore, nerol was readily biodegradable.
Reference
Table 5.2.1/1: Dissolved oxygen concentrations (mg/L) in the closed bottles
Time (days) |
Oxygen concentration (mg/L) |
|||
Ocs |
Ot |
Oc |
Oa |
|
0 |
9.1 |
9.1 |
9.1 |
9.1 |
|
9.1 |
9.1 |
9.1 |
9.1 |
Mean (M) |
9.1 |
9.1 |
9.1 |
9.1 |
7 |
8.4 |
4.6 |
8.6 |
5.0 |
|
8.6 |
4.3 |
8.6 |
5.0 |
Mean (M) |
8.5 |
4.5 |
8.6 |
5.0 |
14 |
8.2 |
3.1 |
8.3 |
4.0 |
|
8.2 |
3.5 |
8.3 |
4.2 |
Mean (M) |
8.2 |
3.3 |
8.3 |
4.1 |
21 |
8.0 |
3.2 |
|
|
|
8.0 |
2.8 |
|
|
Mean (M) |
8.0 |
3.0 |
|
|
28 |
8.0 |
2.9 |
|
|
|
7.9 |
2.6 |
|
|
Mean (M) |
8.0 |
2.8 |
|
|
Ocs: River water with nutrients and silica gel but without test material
Ot: River water with nutrients, test material (2.0 mg/L), and silica gel
Oc: River water with nutrients
Oa: River water with nutrients and sodium acetate (6.7 mg/L)
Table 5.2.1/2: Oxygen consumption (mg/L) and the percentages biodegradation of the test substance, nerol (BOD/ThOD) and sodium acetate (BOD/ThOD) in the Closed Bottle test
Time (days) |
Oxygen consumption (mg/L) |
Biodegradation (%) |
||
Test substance |
Sodium acetate |
Test substance |
Sodium acetate |
|
0 |
0.0 |
0.0 |
0 |
0 |
7 |
4.0 |
3.6 |
69 |
67 |
14 |
4.9 |
4.2 |
84 |
78 |
21 |
5.0 |
|
86 |
|
28 |
5.2 |
|
90 |
|
Description of key information
Based on a read-across from a GLP study performed according to Guideline OECD 301D on nerol, substance neryl acetate can be considered as readily biodegradable.
For the justification, please see the document provided in section 13.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
One reliable study was available for substance nerol. The biodegradability of the substance was studied according to OECD TG No. 301D and GLP. The biodegradation percentage of the substance reached 90% after 28 days (based on O2 consumption) and the substance met the time window requirement. Thus, the substance is considered as readily biodegradable.
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