Miristalkonium chloride

Boiling point

Administrative data

Endpoint:

boiling point

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

melting point/freezing point

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

From April 04, 2001 to April 11, 2001

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

KL2 due to RA

Justification for type of information:

Refer to section 13 for details on the read-across justification. The study with the read across substance is considered sufficient to fulfil the information requirements as further explained in the provided endpoint summary.

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

not specified

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Key result

Remarks on result:

not determinable

Remarks:

no melting or boiling point could be determined due to decomposition of the test substance

Results of the differential scanning calorimetry

Open crucibles

An endothermal peak could be observed at the tests with open and closed crucibles. The endothermal signal was starting at approximately 160-170°C. The shape of the endothermal peak was wide. At about 220°C the endothermal signal was going to be overlapped by an exothermal decomposition. The reason for these observed processes were the exothermic decomposition of the test substance and the endothermic evaporation of their disintegrated components.

Closed crucibles

Al tests with closed crucible had an additional small exothermal event at approximately 150°C close before the widespread endothermic peak. This exothermal event could be the beginning of the decomposition of test substance, which was followed or possibly overlapped by a wide endothermal peak. At last, a strong exothermal decomposition was starting at approximately 220°C.

The test substance is an ionic chemical. Therefore, the substance could not boil without a preceding decomposition. Due to this chemical property. The test substance has no boiling point.

Based on the test results, the author concluded that the test substance has no melting or boiling point.

Conclusions:

Based on the results of the read across study, a similar behaviour is expected for the test substance, C14 ADBAC.

Executive summary:

A study was conducted to determine the melting point of the test substance, C12-16 ADBAC (Purity: 96.6%), according to the OECD Guideline 102, using differential scanning calorimetry (DSC), in compliance with GLP. The samples of the test substance were weighed into aluminium and stainless steel crucibles and exposed to a temperature/time-gradient while the thermal heat flow was recorded. The test substance was tested at a temperature range of 200 to 400°C. It was known from the test of relative density that the test substance does not melt. With increasing temperature the substance softens and is getting less viscous and clear. The process is reversible, but it needs 12 to 24 h at room temperature to return to the original state again. The measured endo- and exothermal processes could be traced back to a decomposition of the test substance and the evaporation of its disintegrated components. Due to the ionic state of the test substance, boiling without a preceding decomposition is not possible. Based on the study results, the author concluded that the test substance has no melting or boiling point. Under study conditions, the test substance has no melting point or boiling point due to decomposition (Fischer, 2001). Based on the results of the read across study, a similar behaviour is expected for the test substance, C14 ADBAC.