Registration Dossier
Registration Dossier
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EC number: 205-305-4 | CAS number: 137-66-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- other: publication
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The concentration of Asc16 in distilled water at 25 °C was measured by UV-VIS spectroscopy (at λ = 265 nm), using a Shimadzu UV 160-A spectrophotometer.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Asc16 analytical grade
- Water solubility:
- 0 other: mol/L
- Conc. based on:
- test mat.
- Temp.:
- 25 °C
- Remarks on result:
- not measured/tested
- Remarks:
- pH
- Conclusions:
- The water solubility of ascorbyl palmitate at 25 °C was determined to be 8.1E-7 M, corresponding to 0.336 mg/L.
- Executive summary:
Using a photometric analytical method, Palma et al. (2002) determined the solubility of ascorbyl palmitate in distilled water at 25 °C to be 8.1 10-7 M; this corresponds to 0.336 mg/L.
- Endpoint:
- water solubility
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR supporting information for available literature data
- Principles of method if other than guideline:
- QSAR calculation
- GLP compliance:
- no
- Type of method:
- other: QSAR calculation
- Water solubility:
- ca. 0.025 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: QSAR calculation
- Conclusions:
- Water solubility of ascorbyl palmitate at 25 °C was estimated to be 0.02469 mg/L (with a given log Kow of 6.5 and a melting point of 112 °C).
- Executive summary:
Providing the log Kow of 6.5 and melting point of 112 °C, the estimation of the water solubility of ascorbyl palmitate using EpiSuite v4.11 (US EPA) resulted in a value of 0.02469 mg/L (< 1 mg/L).
Referenceopen allclose all
Description of key information
Ascorbyl palmitate is poorly soluble in water, with a water solubility determined to be < 1 mg/L.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
