1,4-bis(p-tolylamino)anthraquinone

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from HSDB and PubChem authoritative databases

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

Environmental bioconcentration factor of the test chemical in fish was estimated using a log Kow and a regression-derived equation.

GLP compliance:

not specified

Radiolabelling:

not specified

Vehicle:

not specified

Test organisms (species):

other: Fish

Route of exposure:

aqueous

Test type:

not specified

Water / sediment media type:

natural water: freshwater

Reference substance (positive control):

not specified

Details on estimation of bioconcentration:

BASIS FOR CALCULATION OF BCF
- Result based on calculated log Pow of: 8.69

Type:

BCF

Value:

500 dimensionless

Basis:

whole body w.w.

Remarks on result:

other: BCF value of test chemical was estimated using a log Kow and a regression-derived equation.

Validity criteria fulfilled:

not specified

Conclusions:

The estimated BCF (bioaccumulation factor) of test chemical in fish was determined to be 500 dimensionless.

Executive summary:

The bioaccumulation study in fishwas conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a log Kow of 8.69 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 500 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-accumulative in aquatic organisms.

Description of key information

The bioaccumulation study in fishwas conducted for estimating the BCF (bioaccumulation factor) value of test chemical (authoritative database, 2017). The bioaccumulation factor (BCF) value was calculated using a log Kow of 8.69 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 500 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-accumulative in aquatic organisms.

Key value for chemical safety assessment

BCF (aquatic species):

500 dimensionless

Additional information

Various studies and predicted data of the test chemical were reviewed for the bioaccumulation end point which are summarized as below:

 

In a key study from authoritative databases (2017), the bioaccumulation study in fishwas conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a log Kow of 8.69 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 500 dimensionless.

 

In a supporting study, the bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical (secondary source, 2005). The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 45.70 dimensionless.

 

For the test chemical, bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical (secondary source, 1987). The bioaccumulation factor (BCF) value was calculated using a log Kow of 6.657 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be ≥ 1000 dimensionless.

 

In a prediction done using the BCFBAF Program of Estimation Programs Interface was used to predict the bioconcentration factor (BCF) of test chemical. The bioconcentration factor (BCF) of test chemical was estimated to be 516.4 L/kg whole body w.w (at 25 deg C).

 

On the basis of above results for test chemical (from authoritative databases, secondary source and modelling database,2018), it can be concluded that the BCF value of test chemical ranges from 45.70 to ≥ 1000, respectively,which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.