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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

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Administrative data

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Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, no GLP compliance, sientifically acceptable
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
-0.274
Temp.:
25 °C
pH:
10.8 - 11.1

amine concentration

Pow

Log Pow

pH

       c/(mol*L-1)

c(octanol)/

c(water)

 

octanol-

phase

water-

phase

 

 

mean

20.4

38.8

0.526

-0.279

 

-0.274

11.1

47.0

84.4

0.556

-0.255

10.9

5.42

10.56

0.513

-0.290

10.8

Conclusions:
A logPow of -0.274 (mean value, 3 measurements at different pH values) is reported for DMA.
Endpoint:
partition coefficient
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Peer-reviewed database; scientifically accepted calculation method
Justification for type of information:
QSAR prediction
Principles of method if other than guideline:
QSAR calculation procedure
GLP compliance:
not specified
Type of method:
other: QSAR
Partition coefficient type:
octanol-water
Analytical method:
not specified
Type:
log Pow
Partition coefficient:
-0.38
Remarks on result:
other: no further information given
Conclusions:
A very low logPow value of -0.38 was calculated, indicating low bioaccumulation potential of the test substance
Executive summary:

A very low logPow value of -0.38 was calculated, indicating low bioaccumulation potential of the test substance.

Endpoint:
partition coefficient
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Peer reviewd database; scientifically accepted calculation procedure
Justification for type of information:
QSAR prediction
Principles of method if other than guideline:
Peer reviewd database; scientifically accepted calculation procedure (according to Hansch & Leo)
GLP compliance:
no
Type of method:
other: QSAR calculation
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
-0.38
Remarks on result:
other: no further information given
Conclusions:
A very low logPow value of -0.38 was calculated, indicating low bioaccumulation potential of the test substance
Executive summary:

A very low logPow value of -0.38 was calculated, indicating low bioaccumulation potential of the test substance.

Description of key information

Partition coefficient (logPow): -0.274. 

Key value for chemical safety assessment

Log Kow (Log Pow):
-0.274
at the temperature of:
25 °C

Additional information

The octanol - water partition coefficient of dimethylamine was experimentally determined by BASF AG in 1988. At a temperature of 25 °C and in the pH range of 10.8 - 11.1 the substance possess a log Pow of -0.274.

Both impartial databases, HSDB and GESTIS, report a logPow of -0.38 for dimethylamine.