Benzyldimethyl(octadecyl)ammonium chloride

Surface tension

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From November 27, 2017 to December 04, 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Deviations:

yes

Remarks:

The deviation has no negative impact on the outcome of the study

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Deviations:

yes

Remarks:

The deviation has no negative impact on the outcome of the study

GLP compliance:

yes (incl. QA statement)

Type of method:

OECD harmonised ring method

Specific details on test material used for the study:

Identity: Benzyldimethyl(octadecyl)ammonium chloride
Batch no: 14217
Appearance: White to off white solid
Composition: Benzyldimethyl(octadecyl)ammonium chloride
Content: Cationic activity 97.6%
Expiry date: 06/2019
Storage conditions: Room temperature, in dark, in closed vessel

Key result

Surface tension:

35.2 mN/m

Temp.:

20 °C

Conc.:

121.9 mg/L

Conclusions:

Under the study condition, surface tension of the aqueous solution of test substance (121.9 mg/L) was determined to be 35.2 mN/m at 20 ± 0.3˚C. As the result is less than 60 mN/m, test substance is considered to be surface active.

Executive summary:

A study was conducted to determine the surface tension of the test substance, C18 ADBAC (active: 97.6%), using a ring method, according to OECD Guideline 115 and EU method A.5, in compliance with GLP. The surface tension of an aqueous solution of the test substance at 121.95 mg/L (verified using HPLC) was measured at 20°C by means of a tensiometer using ring method. Under the study conditions, the surface tension of the test substance was determined to be 35.2 mN/m at 20 ± 0.3˚C. As the result is less than 60 mN/m, test substance was considered to be surface active (Wannenwetsch, 2017).

Reference 2

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

From November 13, 2017 to February 08, 2018

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

non-GLP; surface tension measurements were done directly at 1 g/L

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Deviations:

no

GLP compliance:

no

Remarks:

The study was conducted in a facility which operates in accordance with Good Laboratory Practice principles; however no claim of GLP compliance was intended nor is made for this study

Type of method:

ring method

Key result

Surface tension:

ca. 40 mN/m

Temp.:

20 °C

Conc.:

1 g/L

Due to the complex nature and composition of the test item, it was considered not completely applicable to follow the EC A.5 and OECD 115 guidelines with regard to sample preparation. Therefore, the surface tension of a nominally 1 g/L dispersion of test item in water was used as a worst case scenario based on the maximum sample concentration specified in the guidelines. According to criteria stated in EC Method A.5, substances showing a surface tension lower than 60 mN/m under the conditions of this method should be regarded as being surface active.

Conclusions:

Under the study conditions, the surface tension at nominally 1 g/L of test substance in water was determined to be 40 ± 0.5 mN/m at 20 ± 0.5ºC; therefore it is surface-active.

Executive summary:

A study was conducted to determine the surface tension of the test substance, C18 ADBAC (active: 89.5%), using ring method, according to the OECD Guideline 115 and EU Method A.5. Under the conditions of the study, the surface tension of 1 g/L of test substance (nominal) in water was determined to be 40 ± 0.5 mN/m at 20 ± 0.5ºC. Therefore, the test substance was considered to be surface-active (Envigo, 2018).

Description of key information

The surface tension of the test substance was determined using the ring method, according to OECD Guideline 115 and EU method A.5 (Wannenwetsch, 2017 and Envigo, 2018).

Key value for chemical safety assessment

Surface tension:

35.2

in mN/m at 20°C and concentration in mg/L:

121.9

Additional information

Two studies were available with the test substance:

- Study 1: 35.2 mN/m at 20 ± 0.3˚C and 121.95 mg/L concentration (Wannenwetsch, 2017),

- Study 2: 40 mN/m at 20 ± 0.5˚C and 1 g/L concentration (Envigo, 2018).

The study with lower surface tension value has been taken forward for hazard/risk assessment.