Registration Dossier
Registration Dossier
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EC number: 203-983-6 | CAS number: 112-54-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The test substance was assessed for microbial inhibition in support of the regulation DIN 38412 L8. The NOEC was 16 mg/L. Furthermore, a toxicity control was included in a ready biodegradability test which showed no inhibition at a test concentration of 100mg/L. This can also be used to derive a NOEC for toxicity to microorganisms. The latter, has been chosen for the purposes of the CSA in order to derive the PNECstp.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
The test substance was assessed for microbial inhibition in support of the regulation DIN 38412 L8. The organism used in this study is Pseudomonas putida, which is representative of heterotrophic microorganisms in freshwater. Nine concentrations were tested and none demonstrated toxic effects. The results showed that the 16 h EC50 of the test substance was >16 mg/L, based on growth inhibition. The NOEC is considered to be 16 mg/L.
Information from existing and quality-assured microbial inhibition tests, including data from P. putida may be used to derive a PNECstp (ECHA guidance R.7.8.19.3). However, preference is usually given to data from an activated sludge respiration inhibition test (OECD 209) with the following order of increasing sensitivities among particular test systems suggested: respiration inhibition test < inhibition control in base-set tests < growth inhibition test with P. putida < inhibition of nitrification (R.7.8.17.1). An activated sludge respiration study is not available for dodecanal. However, an inhibition control was included in a ready biodegradability screening test. As this system is considered more sensitive than P.putida, the information from the ready biodegradation inhibition is considered more suitable for derivation of a NOEC for toxicity to microorganisms. No toxicity was observed in the test cultures at a concentration of 100mg/L. This concentration can be used as a NOEC value.
Furthermore, According to Regulation (EC) No. 1907/2006, Annex VIII, testing for this endpoint is not required if the substance is found to be readily biodegradable and the applied test concentrations are in the range of concentrations that can be expected in the influent of a sewage treatment plant. The substance has been tested and shown to be readily biodegradable. Therefore no further testing is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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