Registration Dossier
Registration Dossier
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EC number: 203-960-0 | CAS number: 112-33-4
Endpoint summary
Administrative data
Description of key information
oral - LD50 male = 6500 mg/kg bw - Smyth et al. 1969
inhalation/whole body - no mortality observed - Smyth et al. 1969
dermal - LD50 male = 6330 mg/kg bw - Smyth et al. 1969
Key value for chemical safety assessment
Additional information
In an acute oral toxicity study (Smyth et al. 1969), where only limited data is provided, groups of 5 male Carworth-Wistar rats were given a single oral dose of 3-Aminopropoxy-2-ethoxy ethanol and observed for 14 days. Based upon mortalities observed during the 14 day period the most probable LD50value and its fiducial range are estimated by the method of Thompson using tables of Weil:
Oral LD50 males = 6500 mg/kg bw (4950 - 8530)
In the same study 6 male or female albino rats were exposed by inhalation route to 3-Aminopropoxy-2-ethoxy for 8 hours to whole body. Animals then were observed for 14 days. None of the exposed animals died.
Additionally, acute dermal toxicity was tested similar to the one day cuff method by Draize. Groups of 4 immobilized male albino New Zealand rabbits were dermally exposed to the test substance for 24 hours. Animals then were observed for 14 days. Based upon mortalities observed during the 14 day period the most probable LD50value and its fiducial range are estimated by the method of Thompson using tables of Weil:
Dermal LD50Males = 6330 mg/kg bw (4514 - 8902)
3-Aminopropoxy-2-ethoxy ethanol is virtually non-toxicity based on the oral and dermal LD50values in males and doesn't present an acute hazard by inhalation.
Justification for classification or non-classification
DSD and CLP classification are not warranted for 3-Aminopropoxy-2-ethoxy ethanol.
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